Prognostic value of dynamic changes in C‑reactive protein‑albumin ratio for patients with spontaneous intracerebral hemorrhage

<p>To examine the predictive value of the C‑reactive protein‑albumin ratio (CAR) measured at distinct time points.</p> <p>Multivariate logistic regression was applied to examine the links of CAR 1 (at admission), CAR 2 (7th day after admission), and ΔCAR (change between CAR 1 and CAR 2) with 3-month prognosis.</p> <p>CAR 2 (AUC = 0.704, 95%CI: 0.650–0.757) yielded a statistically significantly higher predictive performance for the 3-month prognosis relative to CAR 1 (AUC = 0.624, 95%CI: 0.563–0.685) and ΔCAR (AUC = 0.624, 95%CI: 0.563–0.685) (for CAR 1 or ΔCAR vs. CAR 2, both <i>p</i> < 0.05).

The ICH score + CAR 2 (AUC = 0.817, 95%CI: 0.764–0.869) provided significantly increased predictive efficacy versus the ICH score alone (AUC = 0.776, 95%CI: 0.717–0.835) (<i>p</i> = 0.018). Similarly, the predictive performance of the ICH index + CAR 2 (AUC = 0.810, 95%CI: 0.762–0.859) surpassed that of the ICH index alone (AUC = 0.772, 95%CI: 0.721–0.823) (<i>p</i> = 0.004).</p> <p>CAR measured on the 7th day of admission was markedly linked to a poor 3-month prognosis and significantly increased predictive efficacy of existing prognostic scoring systems for patients with ICH.