Exploring the antidiabetic potential of DHA-salicylaldehyde-chalcone endowed 1,2,3-triazole hybrids: synthesis, α-glucosidase inhibition and molecular modeling studies

<p>The present research work aims to synthesize and explore the <i>in vitro</i> α-glucosidase inhibition potentials of DHA-salicylaldehyde-chalcone endowed 1,2,3-triazoles to counter diabetes mellitus.</p> <p>A series of DHA-salicylaldehyde-chalcone endowed 1,2,3-triazole hybrids (<b>4a-4l</b>) was synthesized and characterized using various spectral techniques <i>viz</i> FTIR, NMR, and HRMS. The hybrids were further assayed for <i>in vitro</i> α-glucosidase inhibition.

The findings were further justified by <i>in silico</i> studies.</p> <p>The findings of <i>in vitro</i> study suggested triazole hybrid <b>4k</b> as the most potent α-glucosidase inhibitor (IC₅₀ = 1.35 µM) compared to acarbose (IC₅₀ = 13.5 µM). Molecular docking (MD) investigations of ligand-protein complex revealed favorable binding interactions.</p> <p>The hybrid <b>4k</b> exhibited maximum inhibition of α-glucosidase enzyme with favorable binding interactions, suggesting this framework is a potential lead motif for future antidiabetic drug discovery.</p>