Multispectral diffuse optical tomography of healthy human finger joints

Diffuse optical tomography (DOT) provides information about underlying functional properties of biological tissue. To detect pathophysiological changes in inflamed RA joints, a good understanding of baseline values for healthy subjects is first required.

Finger joints from healthy subjects were imaged using a non-contact, multispectral, continuous wave DOT system, recovering physiological parameters of oxygen saturation, total haemoglobin, water concentration and scatter amplitude. Reconstructed values across the cohort demonstrated good consistency between finger joints from the same participant, with greater variation seen between subjects.