Table 1_Joint effects of diabetes and time-weighted average multidimensional nutritional indices on mortality in patients undergoing peritoneal dialysis: a landmark analysis.docx

Furthermore, interaction analyses and restricted cubic spline models were applied to ascertain whether diabetes modulated the relationship between longitudinal nutritional status and mortality risk.</p>Results<p>The study cohort comprised 229 patients undergoing PD, with an average age of 48.68 ± 13.42 years; 87 of these patients had diabetes. Among the longitudinal nutritional indices evaluated, the TWA-CONUT score demonstrated the highest predictive accuracy for both all-cause and cardiovascular mortality.

Both diabetes and a poorer long-term nutritional status were independently linked to an elevated risk of death. Patients presenting with both diabetes and malnutrition experienced substantially higher risks of all-cause mortality and cardiovascular mortality, with HRs of 5.10 (95% CI, 2.08–12.48) and 6.86 (95% CI, 1.93–24.32), respectively. A statistically significant interaction was observed between diabetes status and the TWA-CONUT score concerning all-cause mortality (P for interaction = 0.0037).</p>Conclusion<p>The integration of the TWA-CONUT score with diabetes status holds potential for identifying PD patients at an elevated risk of mortality.

Specifically, individuals with both diabetes and chronic malnutrition faced significantly increased risks of all-cause and cardiovascular mortality.</p>