β-hydroxybutyrate Induces upregulation of Glutamate Uptake and Transporter Expression in Astrocytes

Astrocytes are the most abundant glial cells in central nervous system which have been proved to play a pivotal role in the development and progression of neurodegenerative diseases. BHB is known to alter neuronal metabolism and function, but its effects on astrocytes are poorly understood.

Here we carried out the transcriptome sequencing analysis to examine differential expression genes induced by BHB in astrocytes and identified that slc1a3 which encoding the glutamate transporter EAAT1 was significantly upregulated in BHB treatment. Our findings suggested a novel mechanism for the neuroprotective effects of BHB and reinforced the beneficial effect of BHB on central nervous system (CNS).