Data · dataset · 2026
<p>FABP5 expression correlates with immune infiltration and immunosuppressive microenvironment.</p>
Listed in ZivaHub
<p>(A) Boxplots of normalized gene expression after batch correction.
Description
(B) PCA plots demonstrating the effectiveness of batch effect removal. (C) Relative abundance of 22 immune cell subsets estimated by CIBERSORT.
(D) Differential infiltration analysis of immune cell populations between tumor and normal tissues. (E) Correlation matrix of infiltrating immune cells. (F) Correlation analysis between FABP5 expression and immune cell abundance.
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(G) TIDE analysis showing higher TIDE scores in FABP5-high patients, suggesting resistance to immune checkpoint blockade therapy. (H) Upregulation of multiple immune checkpoint molecules (e.g., PD-L1, CTLA-4, PD-1) in FABP5-high tumors. (I) ESTIMATE analysis confirmed higher stromal and immune scores in the FABP5-high group.
G1: Group 1 (High Expression); G2: Group 2 (Low Expression). *<i>p</i> < 0.05, **<i>p</i> < 0.01, ***<i>p</i> < 0.001.</p>
Links
Where it is published
- DOI doi.org/10.1371/journal.pone.0356359.g006 ↗
DOI / persistent id · from zivahub uct ac za
Catalogue records · 1
- OAI-PMH record api.figshare.com/v2/oai?verb=GetRecord&metadataPrefix=oai_dc&identifier=oai%3Af… ↗
metadata API · from zivahub uct ac za
Topics
- From keywords
- Cancer · Chemistry · Earth & Environmental Science · Genetics · Immunology · Life Sciences · Medicine & Health
Provenance · 1 source records, 12 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| ZivaHub | oai:figshare.com:article/34027512 | 12 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | |
| concepts[disease].local:disease:cancer | mapping · zivahub uct ac za | vocabulary-mapper@1.0.0 | keywords['Cancer'] |
| concepts[field].anzsrc:group:3105 | mapping · zivahub uct ac za | vocabulary-mapper@1.0.0 | keywords['Genetics'] |
| concepts[field].anzsrc:group:3204 | mapping · zivahub uct ac za | vocabulary-mapper@1.0.0 | keywords['Immunology'] |
| concepts[field].local:field:chemistry | mapping · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | |
| concepts[field].local:field:earth-environmental | mapping · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | |
| concepts[field].local:field:life-sciences | mapping · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | |
| concepts[field].local:field:medicine-health | mapping · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | |
| description | source · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | /metadata/dc/description |
| license | source · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | /metadata/dc/rights |
| publication_date | source · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | |
| title | source · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | /metadata/dc/title |