Sequence defined foldamers for the synthesis of β-strand mimetics and macrocycles

These molecules are able to adopt a well-defined structure, capable or replicating or selectively inhibiting some of Nature’s most important biological interactions. Chapter 1: Introduces the concept of foldamers and how they relate to peptide secondary and tertiary structure.

This chapter will be focused solely on reviewing the most important and exciting literature in the field. Chapter 2: Focuses on the synthesis of a 1,3-linked pyrrolinone β-strand mimic that can project R-group substituents both above and below the plane. These compounds were designed with the selective interruption of protein-protein interactions in mind.