Table · dataset · 2019
Data for Reducing RSV hospitalisation in a lower-income country by vaccinating mothers-to-be and their households
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Respiratory syncytial virus is the leading cause of lower respiratory tract infection among infants.
Description
RSV is a priority for vaccine development. In this study, we investigate the potential effectiveness of a two-vaccine strategy aimed at mothers-to-be, thereby boosting maternally acquired antibodies of infants, and their household cohabitants, further cocooning infants against infection.
We use a dynamic RSV transmission model which captures transmission both within households and communities, adapted to the changing demographics and RSV seasonality of a low-income country. Model parameters were inferred from past RSV hospitalisations, and forecasts made over a 10-year horizon. We find that a 50% reduction in RSV hospitalisations is possible if the maternal vaccine effectiveness can achieve 75 days of additional protection for newborns combined with a 75% coverage of their birth household co-inhabitants (∼7.5% population coverage).<br><br>Data record consists of 3 data files in .jld format, and an accompanying readme file.
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These dataset(s) contain RSV hospitalization data, individual type distributions, and household type distributions. We developed a mathematical model for simulating RSV transmission amongst households in Kilifi county. The model was parameterized using anonymised datasets generated from the Kilifi Demographic and Health surveillance system (KDHSS), and, daily reports of confirmed RSV hospitalisations at Kilifi county hospital (KCH).
The datasets derived from the underlying KDHSS dataset were generated by filtering for people alive and living in Kilifi county on the 1st Jan 2000, 2001, … , 2017. Each person was described by an age category, the number of members of her household, and whether the household contained an under-one year old. Each household was described by the number of over-one year olds and under-one year olds.
These data sets, and metadata such as the start and end times of each age category were stored as vectors of arrays in .jld format.
Links
Where it is published
- DOI doi.org/10.82444/warw.33803371.v1 ↗
DOI / persistent id · from figshare com
Catalogue records · 1
- OAI-PMH record api.figshare.com/v2/oai?verb=GetRecord&metadataPrefix=oai_dc&identifier=oai%3Af… ↗
metadata API · from figshare com
Topics
Provenance · 1 source records, 16 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| figshare | oai:figshare.com:article/33803371 | 9 d ago | JSON v1 |
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| description | source · figshare com | connector:figshare_com@1.0.0 | /metadata/dc/description |
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| publication_date | source · figshare com | connector:figshare_com@1.0.0 | |
| title | source · figshare com | connector:figshare_com@1.0.0 | /metadata/dc/title |