Data · dataset · 2026
Pan-MKK inhibition by myricetin disrupts microglial p38 signaling to rescue sleep deprivation-induced neuropsychiatric disturbances
Listed in Teesside University Research Data Repository
We delineate the molecular pathogenesis of SD-induced neuropsychiatric impairments and establish SX as a multi-target therapeutic intervention.
Description
SX corrects behavioral deficits by suppressing hippocampal microglial M1 polarization through inhibition of p38 phosphorylation. Crucially, we identify myricetin as a novel broad-spectrum inhibitor of microglial p38 activation that directly binds p38 and disrupts MKK-mediated phosphorylation, serves as primary active constituent of SX against SD pathology.
Links
Where it is published
- DOI doi.org/10.17632/vzrmtkcs7f.1 ↗
DOI / persistent id · from researchdata tees ac uk
Catalogue records · 1
- OAI-PMH record data.mendeley.com/oai?verb=GetRecord&metadataPrefix=oai_dc&identifier=oai%3Adata… ↗
metadata API · from researchdata tees ac uk
Topics
- From keywords
- Earth & Environmental Science
Provenance · 1 source records, 6 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| Teesside University Research Data Repository | oai:data.mendeley.com/vzrmtkcs7f.1 | 9 h ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · researchdata tees ac uk | connector:researchdata_tees_ac_uk@1.0.0 | |
| concepts[field].local:field:earth-environmental | mapping · researchdata tees ac uk | connector:researchdata_tees_ac_uk@1.0.0 | |
| description | source · researchdata tees ac uk | connector:researchdata_tees_ac_uk@1.0.0 | /metadata/dc/description |
| license | source · researchdata tees ac uk | connector:researchdata_tees_ac_uk@1.0.0 | /metadata/dc/rights |
| publication_date | source · researchdata tees ac uk | connector:researchdata_tees_ac_uk@1.0.0 | |
| title | source · researchdata tees ac uk | connector:researchdata_tees_ac_uk@1.0.0 | /metadata/dc/title |