Table · dataset · 2026
Data Sheet 1_Graphene oxide-engineered dental implants: orchestrating antibacterial defense and osteo-immunomodulation for enhanced osseointegration.docx
Listed in figshare and Loughborough Research Repository — shown once because both records carry DOI 10.3389/fbioe.2026.1943704.s001
<p>Dental implant technology has brought significant benefits to millions of patients with missing teeth, substantially improving their quality of life.
Description
However, titanium-based dental implants still face two stubborn problems—peri-implant infection and inadequate osseointegration, which seriously undermine their therapeutic outcomes and overall clinical success. To address these two key bottlenecks, this study developed a graphene oxide (Graphene oxide)-engineered dental implant endowed with synergistic antibacterial and osteoimmunomodulatory properties.
This implant exhibited broad-spectrum antibacterial effects against three common pathogenic strains in dentistry by disrupting bacterial cell membranes and increasing intracellular reactive oxygen species (ROS) levels. Moreover, the implant regulated the macrophage polarization toward a pro-regenerative phenotype, thereby optimizing the local immune microenvironment and promoting the extension and differentiation of osteoblasts.
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In vivo studies confirmed that GO-engineered implants enhanced antibacterial defenses, promoted inflammation resolution, and accelerated osteogenic regeneration. These results suggest the preclinical potential of GO-based surface modification for dental implants. By integrating antibacterial, immunomodulatory, and osteogenic functions, this implant demonstrates promising preliminary performance in promoting early osseointegration and short-term local biological stability, offering a candidate strategy for further implant design.</p>
Links
Where it is published
- DOI doi.org/10.3389/fbioe.2026.1943704.s001 ↗
DOI / persistent id · from figshare com
Catalogue records · 1
- OAI-PMH record api.figshare.com/v2/oai?verb=GetRecord&metadataPrefix=oai_dc&identifier=oai%3Af… ↗
metadata API · from figshare com
Topics
- From keywords
- Astronomy & Astrophysics · Chemistry · Chemistry · Computer Science & AI · Computer Science & AI · Earth & Environmental Science · Earth & Environmental Science · Economics & Finance · Economics & Finance · Engineering · Engineering · Humanities · Humanities · Life Sciences · Life Sciences · Materials Science · Mathematics & Statistics · Medicine & Health · Medicine & Health · Ocean & Atmospheric Science · Psychology & Behavioral Science · Social Science · Social Science
- Inferred from text
- Dentistry 72%
Provenance · 2 source records, 29 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| figshare | oai:figshare.com:article/33970327 | 11 d ago | JSON v1 |
| Loughborough Research Repository | oai:figshare.com:article/33970327 | 11 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · figshare com | connector:figshare_com@1.0.0 | |
| concepts[field].anzsrc:group:3203 | enrichment · figshare com | taxonomy-embedding@1.0.0 | title+keywords+description (72%) |
| concepts[field].local:field:astronomy | mapping · figshare com | connector:figshare_com@1.0.0 | |
| concepts[field].local:field:chemistry | mapping · figshare com | connector:figshare_com@1.0.0 | |
| concepts[field].local:field:chemistry | mapping · repository lboro ac uk | connector:repository_lboro_ac_uk@1.0.0 | |
| concepts[field].local:field:computer-science-ai | mapping · figshare com | connector:figshare_com@1.0.0 | |
| concepts[field].local:field:computer-science-ai | mapping · repository lboro ac uk | connector:repository_lboro_ac_uk@1.0.0 | |
| concepts[field].local:field:earth-environmental | mapping · figshare com | connector:figshare_com@1.0.0 | |
| concepts[field].local:field:earth-environmental | mapping · repository lboro ac uk | connector:repository_lboro_ac_uk@1.0.0 | |
| concepts[field].local:field:economics-finance | mapping · figshare com | connector:figshare_com@1.0.0 | |
| concepts[field].local:field:economics-finance | mapping · repository lboro ac uk | connector:repository_lboro_ac_uk@1.0.0 | |
| concepts[field].local:field:engineering | mapping · repository lboro ac uk | connector:repository_lboro_ac_uk@1.0.0 | |
| concepts[field].local:field:engineering | mapping · figshare com | connector:figshare_com@1.0.0 | |
| concepts[field].local:field:humanities | mapping · figshare com | connector:figshare_com@1.0.0 | |
| concepts[field].local:field:humanities | mapping · repository lboro ac uk | connector:repository_lboro_ac_uk@1.0.0 | |
| concepts[field].local:field:life-sciences | mapping · figshare com | connector:figshare_com@1.0.0 | |
| concepts[field].local:field:life-sciences | mapping · repository lboro ac uk | connector:repository_lboro_ac_uk@1.0.0 | |
| concepts[field].local:field:materials-science | mapping · repository lboro ac uk | connector:repository_lboro_ac_uk@1.0.0 | |
| concepts[field].local:field:mathematics-statistics | mapping · repository lboro ac uk | connector:repository_lboro_ac_uk@1.0.0 | |
| concepts[field].local:field:medicine-health | mapping · figshare com | connector:figshare_com@1.0.0 | |
| concepts[field].local:field:medicine-health | mapping · repository lboro ac uk | connector:repository_lboro_ac_uk@1.0.0 | |
| concepts[field].local:field:ocean-atmospheric | mapping · figshare com | connector:figshare_com@1.0.0 | |
| concepts[field].local:field:psychology-behavioral | mapping · repository lboro ac uk | connector:repository_lboro_ac_uk@1.0.0 | |
| concepts[field].local:field:social-science | mapping · figshare com | connector:figshare_com@1.0.0 | |
| concepts[field].local:field:social-science | mapping · repository lboro ac uk | connector:repository_lboro_ac_uk@1.0.0 | |
| description | source · figshare com | connector:figshare_com@1.0.0 | /metadata/dc/description |
| license | source · figshare com | connector:figshare_com@1.0.0 | /metadata/dc/rights |
| publication_date | source · figshare com | connector:figshare_com@1.0.0 | |
| title | source · figshare com | connector:figshare_com@1.0.0 | /metadata/dc/title |