Data · dataset · 2025
Precision imaging of individual human brains during deep brain stimulation (open-DBS)
Listed in ScienceDB
Deep brain stimulation (DBS) is an effective treatment for Parkinson’s disease (PD) but its neural mechanisms remain poorly understood.
Description
A mechanistic understanding requires precise characterization of functional responses to various stimulation conditions within the same individual. Here, we leveraged recent advancements in 3T MRI-compatible DBS and precision imaging to collect extensive data from 14 PD patients who received DBS.
Across five timepoints spanning one year, each patient underwent 11.7-hour fMRI under seven stimulation conditions (30-172 minutes/session), 2.2-hour structural MRI (26 min/session), 1.3-hour diffusion-weighted MRI (16 min/session), and neurological assessments. This densely-sampled dataset provides reliable, individual-specific functional measures.Dataset description:Fourteen patients with PD underwent assessment one month before and 1, 3, 6, and 12 months after STN-DBS surgery.
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In the presurgical visit, five modalities of sMRI (T1w imaging, T2w FLAIR, T2w imaging with both coronal and transversal views, QSM, and blood vessel enhanced MRA), dMRI (diffusion-weighted NODDI), 30 min (6 min × 5 runs) of resting-state fMRI, and UPDRS-III assessments from two independent neurologists were completed. Following surgery, patients underwent sMRI and dMRI scans using identical protocols as presurgery.
Twenty-four min (6 min × 4 runs) of fMRI scanning were acquired under each of the 7 stimulation conditions (DBS OFF as well as continuous/block-design HFS, LFS, and VFS). Postsurgical UPDRS-III assessments were conducted for each of the 4 stimulation conditions (DBS OFF, continuous HFS, LFS, and VFS), by two neurologists, independently.
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Where it is published
- DOI doi.org/10.57760/sciencedb.26302 ↗
DOI / persistent id · from scidb cn
Catalogue records · 1
- OAI-PMH record scidb.cn/oai?verb=GetRecord&metadataPrefix=oai_dc&identifier=10.57760%2… ↗
metadata API · from scidb cn
Topics
- From keywords
- Earth & Environmental Science · Engineering · Humanities · Life Sciences · Medicine & Health · Social Science
- Inferred from text
- Disease 75% · Imaging 75% · Magnetic resonance imaging 65% · Neurosciences 69%
Provenance · 1 source records, 15 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| ScienceDB | 10.57760/sciencedb.26302 | 11 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · scidb cn | connector:scidb_cn@1.0.0 | |
| concepts[disease].local:disease:disease | enrichment · scidb cn | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[field].anzsrc:group:3209 | enrichment · scidb cn | taxonomy-embedding@1.0.0 | title+keywords+description (69%) |
| concepts[field].local:field:earth-environmental | mapping · scidb cn | connector:scidb_cn@1.0.0 | |
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| concepts[field].local:field:humanities | mapping · scidb cn | connector:scidb_cn@1.0.0 | |
| concepts[field].local:field:life-sciences | mapping · scidb cn | connector:scidb_cn@1.0.0 | |
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| concepts[modality].local:modality:imaging | enrichment · scidb cn | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[modality].local:modality:mri | enrichment · scidb cn | keyword-concept-rules@1.0.0 | title+description (65%) |
| description | source · scidb cn | connector:scidb_cn@1.0.0 | /metadata/dc/description |
| license | source · scidb cn | connector:scidb_cn@1.0.0 | /metadata/dc/rights |
| publication_date | source · scidb cn | connector:scidb_cn@1.0.0 | |
| title | source · scidb cn | connector:scidb_cn@1.0.0 | /metadata/dc/title |