Data · dataset · 2026
<p>Antigenic profiles of nucleoporins.</p>
Listed in ZivaHub
<div><p><i>Plasmodium vivax</i> is the second most prevalent <i>Plasmodium</i> species, with 2.5 billion people at risk of infection worldwide and around 10 million cases of clinical vivax malaria every year.
Description
Despite the clinical importance of this pathogen, little is known about the <i>P. vivax</i> proteins recognized by the host immune system, which hinders our ability to select vaccine candidates or to develop efficient serological markers.
To characterize immunogenic <i>P. vivax</i> proteins, we designed a high-density peptide array containing 4.2 million peptides covering the entire protein sequences of all <i>P. vivax</i> genes and analyzed antibody responses of infected and malaria-naïve individuals. We identified a total of 283 proteins that are commonly immunogenic in symptomatic individuals. These proteins included many proteins known to be involved in erythrocyte invasion, several nucleoporins, and many uncharacterized proteins that should be further investigated for their roles during blood-stage infections.
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These analyses also revealed a unique pattern of antibody response against PIR proteins in asymptomatic individuals that could be associated with protection against clinical vivax malaria. Overall, these data provide an agnostic and proteome-wide perspective on immunogenic <i>P. vivax</i> proteins and constitute an important resource for the malaria community to develop new tools for better detecting and eliminating this important human pathogen.</p></div>
Links
Where it is published
- DOI doi.org/10.1371/journal.ppat.1014621.s011 ↗
DOI / persistent id · from zivahub uct ac za
Catalogue records · 1
- OAI-PMH record api.figshare.com/v2/oai?verb=GetRecord&metadataPrefix=oai_dc&identifier=oai%3Af… ↗
metadata API · from zivahub uct ac za
Topics
- From keywords
- Earth & Environmental Science · Immunology · Infectious diseases · Life Sciences · Medicine & Health · Microbiology
Provenance · 1 source records, 11 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| ZivaHub | oai:figshare.com:article/34017727 | 12 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | |
| concepts[field].anzsrc:field:320211 | mapping · zivahub uct ac za | vocabulary-mapper@1.0.0 | keywords['Infectious Diseases'] |
| concepts[field].anzsrc:group:3107 | mapping · zivahub uct ac za | vocabulary-mapper@1.0.0 | keywords['Microbiology'] |
| concepts[field].anzsrc:group:3204 | mapping · zivahub uct ac za | vocabulary-mapper@1.0.0 | keywords['Immunology'] |
| concepts[field].local:field:earth-environmental | mapping · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | |
| concepts[field].local:field:life-sciences | mapping · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | |
| concepts[field].local:field:medicine-health | mapping · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | |
| description | source · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | /metadata/dc/description |
| license | source · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | /metadata/dc/rights |
| publication_date | source · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | |
| title | source · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | /metadata/dc/title |