Data · dataset · 2026
Preparation of pH-sensitive/folic acid-modified apigenin liposomes and its in vivo anti-tumor effect
Listed in ScienceDB
Description
This study aims to construct pH-sensitive/folic acid-modified apigenin liposomes (pH/FA-Api-Lips), and to conduct pharmacokinetics, tissue distribution and in vivo anti-tumor evaluation. pH/FA-Api-Lips were prepared by film-hydration method, and its physicochemical properties were characterized. Drug release behavior of pH/FA-Api-Lips in phosphate buffer saline solution with different pH values was investigated.
HepG2 cells were used to establish the hepatoma-bearing mice model, apigenin and pH/FA-Api-Lips were intravenously injected to the hepatoma-bearing mice at dose of 20 mg/kg. The pharmacokinetics, tissue distribution and anti-tumor effects of pH/FA-Api-Lips in vivo were also investigated. The results showed that average envelopment efficiency, drug loading, particle size and Zeta potential were 92.26% ± 1.72%, 7.49% ± 0.18%, 212.69 ± 7.07 nm and – 21.27 ± 0.59 mV, respectively.
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The appearance of pH/FA-Api-Lips was vesicular, and the in vitro drug release exhibited obvious pH-sensitivity. pH/FA-Api-Lips enhanced the bioavailability of apigenin, the relative uptake efficiency and peak concentration ratio of apigenin in tumor tissue was increased by 2.64-fold and 1.82-fold, respectively. The results of the pharmacological experiments in vivo showed that pH/FA-Api-Lips significantly inhibited the tumor volume growth in hepatoma-bearing mice, and there was no significant decrease in body weight. pH/FA-Api-Lips increased the tumor inhibition rate of apigenin from 26.76% to 66.67%.
Therefore, pH/FA-Api-Lips improved the tumor targeting of apigenin in vivo, and enhanced the anti-tumor efficacy. pH/FA-Api-Lips had the potential to be developed into an anti-tumor drug.
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Where it is published
- DOI doi.org/10.57760/sciencedb.nprd.00106 ↗
DOI / persistent id · from scidb cn
Catalogue records · 1
- OAI-PMH record scidb.cn/oai?verb=GetRecord&metadataPrefix=oai_dc&identifier=10.57760%2… ↗
metadata API · from scidb cn
Topics
- From keywords
- Earth & Environmental Science · Engineering · Humanities · Life Sciences · Social Science
- Inferred from text
- Cancer 65%
Provenance · 1 source records, 11 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| ScienceDB | 10.57760/sciencedb.nprd.00106 | 11 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · scidb cn | connector:scidb_cn@1.0.0 | |
| concepts[disease].local:disease:cancer | enrichment · scidb cn | keyword-concept-rules@1.0.0 | title+description (65%) |
| concepts[field].local:field:earth-environmental | mapping · scidb cn | connector:scidb_cn@1.0.0 | |
| concepts[field].local:field:engineering | mapping · scidb cn | connector:scidb_cn@1.0.0 | |
| concepts[field].local:field:humanities | mapping · scidb cn | connector:scidb_cn@1.0.0 | |
| concepts[field].local:field:life-sciences | mapping · scidb cn | connector:scidb_cn@1.0.0 | |
| concepts[field].local:field:social-science | mapping · scidb cn | connector:scidb_cn@1.0.0 | |
| description | source · scidb cn | connector:scidb_cn@1.0.0 | /metadata/dc/description |
| license_text | source · scidb cn | connector:scidb_cn@1.0.0 | |
| publication_date | source · scidb cn | connector:scidb_cn@1.0.0 | |
| title | source · scidb cn | connector:scidb_cn@1.0.0 | /metadata/dc/title |