The gut microbiome in Lynch Syndrome is distinct from the general population

Lynch syndrome was associated with a distinct gut microbiome composition and function, including increased microbial diversity and enrichment of specific bacterial taxa such as Blautia species and Actinobacteria. Unlike sporadic colorectal cancer, Fusobacterium nucleatum was not enriched.

Microbiome features showed limited ability to detect advanced colorectal neoplasia, highlighting the need for longitudinal studies to clarify the microbiome's role in colorectal cancer development in Lynch syndrome.