Data · dataset · 2026
pH-Responsive EF-TK-GNTs Nanoplatform Orchestrates Chemo-Photothermal Therapy of Osteosarcoma via ERK/mTOR Axis
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Osteosarcoma is the predominant primary bone malignancy in adolescents, and the survival of patients with metastases has remained stagnant for over three decades.
Description
Here, we describe a rationally designed, pH- and NIR-dual-responsive nanotherapeutic system, EF-TK-GNTs, in which ethyl ferulate (EF) is conjugated to gold nanotriangles (GNTs) via a thioketal (TK) linker. This architecture allowed acidic pH-triggered EF release, whereas 808 nm near-infrared (NIR) light elicited a strong hyperthermic response (ΔT > 50 °C).
In K7M2 murine osteosarcoma cells, the chemo-photothermal combination (G4) produced a pronounced combined cytotoxic effect (~74.2% reduction in viability), migration inhibition, and apoptosis. Mechanistically, we observed that 808 nm-induced photothermal stress was accompanied by marked HSP70 upregulation, which may act as a negative regulator contributing to ERK suppression, while the released EF inhibited mTOR activity.
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This dual attenuation of two key pro-survival pathways was associated with disruption of cellular homeostasis and commitment to mitochondrial apoptosis in vitro. These findings suggest that EF-TK-GNTs may serve as a promising chemo-photothermal platform that attenuates ERK-mTOR co-signaling in osteosarcoma cells, providing an in vitro proof-of-concept for further preclinical validation.
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Where it is published
- DOI doi.org/10.57760/sciencedb.012lt ↗
DOI / persistent id · from scidb cn
Catalogue records · 1
- OAI-PMH record scidb.cn/oai?verb=GetRecord&metadataPrefix=oai_dc&identifier=10.57760%2… ↗
metadata API · from scidb cn
Topics
- From keywords
- Earth & Environmental Science · Engineering · Humanities · Life Sciences · Social Science
Provenance · 1 source records, 10 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| ScienceDB | 10.57760/sciencedb.012lt | 11 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · scidb cn | connector:scidb_cn@1.0.0 | |
| concepts[field].local:field:earth-environmental | mapping · scidb cn | connector:scidb_cn@1.0.0 | |
| concepts[field].local:field:engineering | mapping · scidb cn | connector:scidb_cn@1.0.0 | |
| concepts[field].local:field:humanities | mapping · scidb cn | connector:scidb_cn@1.0.0 | |
| concepts[field].local:field:life-sciences | mapping · scidb cn | connector:scidb_cn@1.0.0 | |
| concepts[field].local:field:social-science | mapping · scidb cn | connector:scidb_cn@1.0.0 | |
| description | source · scidb cn | connector:scidb_cn@1.0.0 | /metadata/dc/description |
| license | source · scidb cn | connector:scidb_cn@1.0.0 | /metadata/dc/rights |
| publication_date | source · scidb cn | connector:scidb_cn@1.0.0 | |
| title | source · scidb cn | connector:scidb_cn@1.0.0 | /metadata/dc/title |