Supplementary datasets to publication about Genome wide co-expression analysis of steroid receptors in the mouse brain

Steroid receptors are pleiotropic transcription factors that coordinate adaptation to different physiological states. An important target organ is the brain, but even though their effects are well studied in specific regions, brain-wide steroid receptor targets and mediators remain largely unknown due to the brain complexity.

Here, we tested the idea that novel aspects of steroid action can be identified through spatial correlation of steroid receptors with genome-wide mRNA expression across different regions in the mouse brain. First, we observed significant co-expression of receptors with sets of steroid target genes that were identified in single brain regions. These co-expression relationships were also present in distinct other brain regions, suggestive of as yet unidentified coordinate regulation of brain regions by e.g. glucocorticoids and estrogens.