Data · dataset · 2026
<p>TCGA pan-cancer transcriptomic analyses and organ-level cross-validation.</p>
Listed in ZivaHub
<p><b>A,</b> Spearman correlation between SLC6A4 expression and immune function scores (T-cell Inflamed GEP and Cytotoxic Score) across 20 TCGA solid tumor types.
Description
Asterisks denote FDR < 0.05. <b>B,</b> Distribution of immune phenotypes (Inflamed, Excluded, Desert) among SLC6A4-high samples by cancer type. Asterisks denote Kruskal-Wallis FDR < 0.05. <b>C,</b> Spearman correlation between SLC6A4 and 6 immune cell-type scores.
Only values with FDR < 0.05 are displayed. <b>D,</b> Organ-level cross-validation: clinical irAE hazard ratios (y-axis) mapped to TCGA SLC6A4-immune correlation coefficients (x-axis) for 5 organ systems. Red point indicates thyroid irAE <i>p</i> < 0.05 (log-rank test). The fitted line is exploratory (<i>n</i> = 5).</p>
Links
Where it is published
- DOI doi.org/10.1371/journal.pmed.1005262.g005 ↗
DOI / persistent id · from zivahub uct ac za
Catalogue records · 1
- OAI-PMH record api.figshare.com/v2/oai?verb=GetRecord&metadataPrefix=oai_dc&identifier=oai%3Af… ↗
metadata API · from zivahub uct ac za
Topics
- From keywords
- Cancer · Earth & Environmental Science · Genetics · Immunology · Life Sciences · Medicine & Health · Psychology & Behavioral Science
Provenance · 1 source records, 12 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| ZivaHub | oai:figshare.com:article/34026796 | 10 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | |
| concepts[disease].local:disease:cancer | mapping · zivahub uct ac za | vocabulary-mapper@1.0.0 | keywords['Cancer'] |
| concepts[field].anzsrc:group:3105 | mapping · zivahub uct ac za | vocabulary-mapper@1.0.0 | keywords['Genetics'] |
| concepts[field].anzsrc:group:3204 | mapping · zivahub uct ac za | vocabulary-mapper@1.0.0 | keywords['Immunology'] |
| concepts[field].local:field:earth-environmental | mapping · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | |
| concepts[field].local:field:life-sciences | mapping · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | |
| concepts[field].local:field:medicine-health | mapping · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | |
| concepts[field].local:field:psychology-behavioral | mapping · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | |
| description | source · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | /metadata/dc/description |
| license | source · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | /metadata/dc/rights |
| publication_date | source · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | |
| title | source · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | /metadata/dc/title |