Data · dataset · 2026
Characterisation and bioactivity evaluation of a frog-skin derived peptide, QUB-1931, from the skin secretion of the <i>Odorrana grahami</i>
Listed in ZivaHub and Deakin Research Online and DMU Figshare — shown once because both records carry DOI 10.17034/32640180.v1
Antimicrobial peptides (AMPs) are natural low molecular mass proteins extracted from species of all kingdoms, with a wide range antimicrobial activity against bacteria, viruses, fungi and protozoa.
Description
Compared with traditional antimicrobial drugs, AMPs induce less antimicrobial resistance and have stronger antimicrobial effects. Amphibians have been considered as significant sources of AMPs, and various AMPs have been isolated and characterized from their skin secretions.
Generally, AMPs are characterized by the conserved amino acid sequences, specific secondary structures, hydrophobicity and net positive charges. The aim of this study was to identify and characterise a novel peptide by cloning from the skin secretion of Odorrana grahami. Then, to evaluate the bioactivity of the identified peptide, including its antimicrobial activity, anti-cancer activity and cytotoxicity.
Read the rest (2 more)
In this research, one new AMP, QUB-1931, was identified. As a member of the nigrocin family, QUB-1931 showed relatively strong inhibitory effects against C. albicans, with a minimum significant effective concentration of 32 µM. Also, QUB-1931 demonstrated low cytotoxicity, with a 10% haemolysis concentration of 391.7 µM on horse erythrocytes. These findings suggest that QUB-1931 is an AMP with low cytotoxicity and potential antimicrobial effect against Gram-negative bacteria.
QUB-1931 exerted no significant anticancer activity against a human cancer cell line (NSCLC, H838). Collectively, QUB-1931 showed bioactivity against Gram-negative bacteria and low cytotoxicity, consistent with previous research relevant to the nigrocin family. These findings indicate the potential antimicrobial applications of QUB-1931 for clinical practice, following modification to improve activity.<br><br><i>Thesis is embargoed until 31st December 2029</i>.<br><br>
Links
Where it is published
- DOI doi.org/10.17034/32640180.v1 ↗
DOI / persistent id · from zivahub uct ac za
Catalogue records · 1
- OAI-PMH record api.figshare.com/v2/oai?verb=GetRecord&metadataPrefix=oai_dc&identifier=oai%3Af… ↗
metadata API · from zivahub uct ac za
Topics
- From keywords
- Earth & Environmental Science · Earth & Environmental Science · Earth & Environmental Science · Life Sciences · Life Sciences · Life Sciences
- Inferred from text
- Cancer 75%
Provenance · 3 source records, 12 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| ZivaHub | oai:figshare.com:article/32640180 | 9 d ago | JSON v1 |
| Deakin Research Online | oai:figshare.com:article/32640180 | 9 d ago | JSON v1 |
| DMU Figshare | oai:figshare.com:article/32640180 | 9 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | |
| concepts[disease].local:disease:cancer | enrichment · zivahub uct ac za | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[field].local:field:earth-environmental | mapping · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | |
| concepts[field].local:field:earth-environmental | mapping · figshare dmu ac uk | connector:figshare_dmu_ac_uk@1.0.0 | |
| concepts[field].local:field:earth-environmental | mapping · dro deakin edu au | connector:dro_deakin_edu_au@1.0.0 | |
| concepts[field].local:field:life-sciences | mapping · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | |
| concepts[field].local:field:life-sciences | mapping · dro deakin edu au | connector:dro_deakin_edu_au@1.0.0 | |
| concepts[field].local:field:life-sciences | mapping · figshare dmu ac uk | connector:figshare_dmu_ac_uk@1.0.0 | |
| description | source · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | /metadata/dc/description |
| license_text | source · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | |
| publication_date | source · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | |
| title | source · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | /metadata/dc/title |