Study database for "Association of the humoral immune response with the inflammatory profile in Plasmodium vivax infections in pregnant women"

In samples from the first infection, the presence of total IgG and its subclasses in plasma against PvMSP1 19 protein were also quantified. RESULTS: Previous exposure to malaria, observed by anti-total IgG antibodies to the PvMSP1 19 antigen, increased the inflammatory response to infection when the pregnant woman had malaria during pregnancy. IL-6 and IL-10 levels were positively correlated with parasitemia and with total IgG levels; but they were negatively correlated with the gestational age at delivery from Pv -infected woman.

In multivariate linear regression analyses, IgG 1, 2 and 4 was negatively and positively associated with cytokines IL-6 and IL-10, respectively, in P . vivax- infection. CONCLUSIONS: An association between the humoral immune response and the peripheral inflammatory cytokine profile with the adverse outcomes in malaria in pregnancy by P . vivax was observed. Previous exposure to the parasite can influence the IL-6 and IL-10 response, which is associated with increased parasitemia, reduced maternal weight gain and premature delivery.