Supplementary Figure S4 from Intratumoral Immune Heterogeneity Drives Divergent Outcomes to PD-(L)1 Blockade in Lung Cancer

Inferred ITIH associates with a gradient in immune cell signatures underlying the MFP across three independent clinical cohorts (cohort A-C). a-c, Circular bar plot showing the enrichment scores of 29 immune-related signatures across the different microenvironmental configurations, stratified by predicted ITIH within each MFP category in cohort A (a), B (b) and C (c). The following groups were compared: Hom-IE/MFP-IE (predicted Hom-IE and MFP immune-enriched), Non-Hom-IE/MFP-IE (other predicted class but MFP immune-enriched), Hom-D/MFP-D (predicted Hom-D and MFP immune-depleted), and Non-Hom-D/MFP-D (other predicted class but MFP immune-depleted).

P values were calculated with the Kruskal-Wallis test.</p>