Supplementary file 1_Effectiveness of tailored individual follow-up vs. standard one-day group course on health-related quality of life in patients with post COVID-19 condition: a randomized controlled trial.pdf

Secondary self-reported outcomes included fatigue measured with the Chalder Fatigue Scale, EQ-VAS, and symptom registration. Neuropsychological function was assessed with objective neuropsychological tests.</p>Results<p>60 participants were randomized, the mean age was 46 years (22–66 years), and 43 (72%) were female. Outcome assessments were completed for the primary outcome for 29 participants in each arm.

No significant between-group difference was found in the primary outcome (score difference EQ-5D-5L-index =0.07; 95% CI [-0.18,.04]; p = .11). The adjusted linear model confirmed the absence of significant difference between groups. No persistent significant group differences were observed for any secondary outcomes.

Both groups showed statistically and clinically significant sustained improvements in fatigue and EQ-VAS, as well as significant reductions in the number of symptoms. Within neuropsychological test, both groups demonstrated significant improvement in episodic memory (RAVLT), and the standard course group additionally showed significant improvement in attention (CPT).</p>Conclusion<p>Tailored individual follow-up was not more effective than a standard one-day group course in improving HRQoL in PCC, both based on principles of CBT.

However, significant improvements in both groups were observed in several secondary outcomes, including some objective neuropsychological tests. Larger studies are needed to confirm these results.</p><p>Clinical Trial Registration: clinicaltrials.gov/study/NCT06085911, identifier NCT06085911.</p>