Data · dataset · 2026
<p>The intestinal function of NHR-68 is required for pathogen avoidance behavior.</p>
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<p><b>(A)</b><i>P. aeruginosa</i> occupancy index of wild-type animals fed empty vector control or <i>nhr-68</i> RNAi at 8 h and 12 h. <b>(B)</b> <i>P. aeruginosa</i> occupancy index of MGH171 animals fed empty vector control or <i>nhr-68</i> RNAi at 8 h and 12 h. <b>(C)</b> <i>P. aeruginosa</i> occupancy index of MAH677 animals fed empty vector control or <i>nhr-68</i> RNAi at 8 hr and 12 hr. <b>(D)</b> <i>P. aeruginosa</i> occupancy index for WT, <i>nhr-68(gk708)</i> and <i>nhr-68(gk708);vha-6p::nhr-68</i> animals at 8 h and 12 h after seeding.
The occupancy index was calculated as (<i>N</i><sub>on</sub> lawn/<i>N</i><sub>total</sub>). Data are presented as mean ± SD from three independent experiments (<i>N</i> = 3; <i>n</i> = 90 animals per condition per experiment). <b>(E)</b> Survival of wild-type animals fed empty vector control or <i>nhr-68</i> RNAi on <i>P. aeruginosa</i> at 25 °C. Mean survival times were 2.24 and 2.89 days, respectively. Empty vector vs. <i>nhr-68</i> RNAi, <i>p</i> < 0.0001. <b>(F)</b> Survival of MGH171 animals fed empty vector control or <i>nhr-68</i> RNAi on <i>P. aeruginosa</i> at 25 °C. Mean survival times were 2.23 and 3.02 days, respectively.
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Empty vector vs. <i>nhr-68</i> RNAi, <i>p</i> < 0.0001. <b>(G)</b> Survival of MAH677 animals fed empty vector control or <i>nhr-68</i> RNAi on <i>P. aeruginosa</i> at 25 °C. Mean survival times were 2.27 and 2.28 days, respectively. Empty vector vs. <i>nhr-68</i> RNAi, <i>p</i> = ns. <b>(H)</b> Survival of wild-type N2, <i>nhr-68(gk708)</i>, or <i>nhr-68(gk708);vha-6p::nhr-68</i> animals on <i>P. aeruginosa</i> at 25 °C. Mean survival times were 2.17, 2.81, and 2.40 days, respectively.
Wild-type vs. <i>nhr-68(gk708)</i>, <i>p</i> < 0.0001; Wild-type vs. <i>nhr-68(gk708);vha-6p::nhr-68</i>, <i>p</i> = 0.0145; <i>nhr-68(gk708)</i> vs. <i>nhr-68(gk708);vha-6p::nhr-68</i>, <i>p</i> = 0.0017. Data are presented from three independent experiments, with 90 animals per condition per experiment (<i>N</i> = 3; <i>n</i> = 90 animals per condition per experiment). The Kaplan-Meier method was used to calculate the survival fractions, and statistical significance between survival curves was determined using the log-rank test.
The data underlying this Figure can be found in <a href="plosbiology.org/article/info:doi/10.1371/journal.pbio.3004026#pbio.3004026.s009" target="_blank">S1 Data</a>.</p>
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- DOI doi.org/10.1371/journal.pbio.3004026.g006 ↗
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- Biochemistry and cell biology · Bioinformatics and computational biology · Caenorhabditis elegans · Chemistry · Earth & Environmental Science · Ecology · Genetics · Immunology · Life Sciences · Medicine & Health · Psychology & Behavioral Science · Research, science and technology policy
Provenance · 1 source records, 17 field assertions
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