Data · dataset · 2023
Evaluation of long-term outcomes of direct acting antiviral agents in chronic kidney disease subjects: a single center cohort study.
Listed in Teesside University Research Data Repository
Description
Background
Chronic kidney disease (CKD) population, including kidney transplant recipients (KTRs) and subjects on renal replacement therapy, is particularly vulnerable to unfa-vorable outcomes of chronic hepatitis C (CHC). Currently, there are oral direct- acting antiviral agents (DAAs) available to eradicate the virus with favorable short-terms outcomes, however long-term effects are lacking. The aim of the study was to assess long-term efficacy and safety of DAA therapy in CKD population.
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Methods
An observational, cohort single-center study was performed. Fifty-nine CHC subjects with CKD, treated with DAAs between 2016 and 2018 were enrolled to the study. Safety and efficacy profiles were assessed, including sustained virologic response (SVR), occult hepatitis C infection (OCI) incidence and liver fibrosis.
Results: SVR was achieved in 96 % of cases (n=57). OCI was diagnosed only in one subject following SVR. Signifi-cant Liver stiffness regression has been observed 4 years following SVR compered to baseline values (Mdn = 6.1 kPa, IQR = 3.75 kPa; 4.9 kPa,IQR = 2.9 kPa), p <0.001.
Most common adverse events were anemia, weakness and urinary tract infection. Conclusion: DAAs provide a safe and effective cure for CHC in both CKD patients and KTRs with favorable safety profile in the long-term follow-up.
Links
Where it is published
- DOI doi.org/10.17632/n3w628yk3t.1 ↗
DOI / persistent id · from researchdata tees ac uk
Catalogue records · 1
- OAI-PMH record data.mendeley.com/oai?verb=GetRecord&metadataPrefix=oai_dc&identifier=oai%3Adata… ↗
metadata API · from researchdata tees ac uk
Topics
- From keywords
- Earth & Environmental Science
- Inferred from text
- Disease 75% · Longitudinal study 65%
Provenance · 1 source records, 8 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| Teesside University Research Data Repository | oai:data.mendeley.com/n3w628yk3t.1 | 16 h ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · researchdata tees ac uk | connector:researchdata_tees_ac_uk@1.0.0 | |
| concepts[disease].local:disease:disease | enrichment · researchdata tees ac uk | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[field].local:field:earth-environmental | mapping · researchdata tees ac uk | connector:researchdata_tees_ac_uk@1.0.0 | |
| concepts[method].local:method:longitudinal-study | enrichment · researchdata tees ac uk | keyword-concept-rules@1.0.0 | title+description (65%) |
| description | source · researchdata tees ac uk | connector:researchdata_tees_ac_uk@1.0.0 | /metadata/dc/description |
| license | source · researchdata tees ac uk | connector:researchdata_tees_ac_uk@1.0.0 | /metadata/dc/rights |
| publication_date | source · researchdata tees ac uk | connector:researchdata_tees_ac_uk@1.0.0 | |
| title | source · researchdata tees ac uk | connector:researchdata_tees_ac_uk@1.0.0 | /metadata/dc/title |