Data · dataset · 2026
Determining the Radiobiological Effects of Clinically Relevant Radiation Dose and Modality in Cervical Cancer
Listed in Teesside University Research Data Repository
The data in these files was collected to study the effects of radiation on cervical cancer cell lines.
Description
We examined the clonogenic survival, DNA repair capacity via gamma-H2AX foci induction and repair, and cytokine secretion following the irradiation by an orthovoltage pre-clinical irradiator, high dose rate brachytherapy remote afterloader, and clinical c-arm style linear accelerator. The alpha/beta ratios were generated using only the pre-clinical irradiator.
All three irradiators were utilized (separately) for the single fraction multi-modality irradiation, gamma-H2AX, and cytokine profiling data. Colonies from the clonogenic data was manually counted using a microscope. Gamma-H2AX foci were counted using CellProfiler where each condition was given its own optimization parameters.
Read the rest (2 more)
This automated counter was validated against manual counting of the same images. The cytokine data was generated from a multiplex immunosorbent assay ran on a fluorescent flow cytometry based Luminex instrument. The conditioned media for this was collected after a 24hr incubation.
Each irradiation and modality was given its own non irradiated sham group. The experimental setup essentially requires this as each irradiator is located in a separate space and thus have different conditions (walk time, etc.).
Links
Where it is published
- DOI doi.org/10.17632/p4tzrd9mv9.1 ↗
DOI / persistent id · from researchdata tees ac uk
Catalogue records · 1
- OAI-PMH record data.mendeley.com/oai?verb=GetRecord&metadataPrefix=oai_dc&identifier=oai%3Adata… ↗
metadata API · from researchdata tees ac uk
Topics
- From keywords
- Earth & Environmental Science · Engineering · Humanities · Life Sciences · Medicine & Health · Physics · Social Science
- Inferred from text
- Cancer 75% · Image 65% · Radiation therapy 78%
Provenance · 1 source records, 15 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| Teesside University Research Data Repository | oai:data.mendeley.com/p4tzrd9mv9.1 | 10 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · researchdata tees ac uk | connector:researchdata_tees_ac_uk@1.0.0 | |
| concepts[disease].local:disease:cancer | enrichment · researchdata tees ac uk | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[field].anzsrc:field:321110 | enrichment · researchdata tees ac uk | taxonomy-embedding@1.0.0 | title+keywords+description (78%) |
| concepts[field].local:field:earth-environmental | mapping · researchdata tees ac uk | connector:researchdata_tees_ac_uk@1.0.0 | |
| concepts[field].local:field:engineering | mapping · researchdata tees ac uk | connector:researchdata_tees_ac_uk@1.0.0 | |
| concepts[field].local:field:humanities | mapping · researchdata tees ac uk | connector:researchdata_tees_ac_uk@1.0.0 | |
| concepts[field].local:field:life-sciences | mapping · researchdata tees ac uk | connector:researchdata_tees_ac_uk@1.0.0 | |
| concepts[field].local:field:medicine-health | mapping · researchdata tees ac uk | connector:researchdata_tees_ac_uk@1.0.0 | |
| concepts[field].local:field:physics | mapping · researchdata tees ac uk | connector:researchdata_tees_ac_uk@1.0.0 | |
| concepts[field].local:field:social-science | mapping · researchdata tees ac uk | connector:researchdata_tees_ac_uk@1.0.0 | |
| concepts[modality].local:modality:image | enrichment · researchdata tees ac uk | keyword-concept-rules@1.0.0 | title+description (65%) |
| description | source · researchdata tees ac uk | connector:researchdata_tees_ac_uk@1.0.0 | /metadata/dc/description |
| license | source · researchdata tees ac uk | connector:researchdata_tees_ac_uk@1.0.0 | /metadata/dc/rights |
| publication_date | source · researchdata tees ac uk | connector:researchdata_tees_ac_uk@1.0.0 | |
| title | source · researchdata tees ac uk | connector:researchdata_tees_ac_uk@1.0.0 | /metadata/dc/title |