Speak to a Protein: An Interactive Multimodal Co-Scientist for Protein Analysis

We introduce <i>Speak to a Protein</i>, a new capability that turns protein analysis into an interactive, multimodal dialogue with an expert coscientist. The AI system retrieves and synthesizes relevant literature, structures, and ligand data; grounds answers in a live 3D scene; and can highlight, annotate, manipulate, and see the visualization.

It also generates and runs code when needed, explaining results in both text and graphics. We demonstrate these capabilities on relevant proteins, posing questions about binding pockets, conformational changes, or structure-activity relationships to test ideas in real time. <i>Speak to a Protein</i> reduces the time from question to evidence, lowers the barrier to advanced structural analysis, and enables hypothesis generation by tightly coupling language, code, and 3D structures. <i>Speak to a Protein</i> is freely accessible at open.playmolecule.org.