Data · dataset · 2023
Pulmonary tuberculosis (PTB) symptomatic individuals, their sociodemographic characteristics, genetic diversity and drug resistance patterns of Mycobacterium tuberculosis strains
Listed in UP Research Data Repository
<p>This dataset described the entire number of adult holy water sites (HWS) attendees (≥18 years of age) who were screened for Pulmonary Tuberculosis (PTB) -suggestive symptoms at nine selected study zones (HWS) found across the study region.
Description
During the study period, a total of 10,313 adult HWS (≥ 18 years of age) were screened, and 560 individuals were PTB symptomatic and participated. Out of 560 PTB symptomatic HWS attendees who participated, 122 (21.8%) were Lowenstein- Jensen (LJ) culture-positive (bacteriologically confirmed cases).
Their sociodemographic characteristics and PTB infection risk factors are detailed. All LJ culture-positive isolates were subjected to spoligotyping, resulting in 116 isolates with interpretable spoligo-patterns. We performed drug susceptibility testing for all 122 (LJ culture)-positive isolates using MTBDRplus v2 and MTBDRsl v2 line probe assays. </p> <p>Drug-susceptibility testing (DST) results for first and second line anti-TB drugs are detailed in this dataset.
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Furthermore, a prospective follow-up study on 438 PTB-symptomatic individuals with culture-negative test results was done to determine the prevalence of developing active TB disease subsequent to residing at a HWS. The duration of follow-up was 12 months, starting on the date that a negative culture result was obtained. Thus, 30 (6.8%) were infected with TB and developed active TB disease post-exposure to HWS.
In general, in these attached datasets, details of the study participants, LJ culture-testing results, DST results, as well as genotyping findings of the isolates are illustrated.</p>
Links
Where it is published
- DOI doi.org/10.25403/upresearchdata.22219072.v1 ↗
DOI / persistent id · from researchdata up ac za
Catalogue records · 1
- OAI-PMH record api.figshare.com/v2/oai?verb=GetRecord&metadataPrefix=oai_dc&identifier=oai%3Af… ↗
metadata API · from researchdata up ac za
Topics
- From keywords
- Disease surveillance · Earth & Environmental Science · Humanities · Major global burdens of disease · Medicine & Health
- Inferred from text
- Disease 75%
Provenance · 1 source records, 11 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| UP Research Data Repository | oai:figshare.com:article/22219072 | 20 h ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · researchdata up ac za | connector:researchdata_up_ac_za@1.0.0 | |
| concepts[disease].local:disease:disease | enrichment · researchdata up ac za | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[field].anzsrc:field:420202 | mapping · researchdata up ac za | vocabulary-mapper@1.0.0 | keywords['Disease surveillance'] |
| concepts[field].anzsrc:field:420207 | mapping · researchdata up ac za | vocabulary-mapper@1.0.0 | keywords['Major global burdens of disease'] |
| concepts[field].local:field:earth-environmental | mapping · researchdata up ac za | connector:researchdata_up_ac_za@1.0.0 | |
| concepts[field].local:field:humanities | mapping · researchdata up ac za | connector:researchdata_up_ac_za@1.0.0 | |
| concepts[field].local:field:medicine-health | mapping · researchdata up ac za | connector:researchdata_up_ac_za@1.0.0 | |
| description | source · researchdata up ac za | connector:researchdata_up_ac_za@1.0.0 | /metadata/dc/description |
| license | source · researchdata up ac za | connector:researchdata_up_ac_za@1.0.0 | /metadata/dc/rights |
| publication_date | source · researchdata up ac za | connector:researchdata_up_ac_za@1.0.0 | |
| title | source · researchdata up ac za | connector:researchdata_up_ac_za@1.0.0 | /metadata/dc/title |