Data · dataset · 2025
A protocol for emulating four published randomised controlled trials using registry data: effects of antibiotics in cystic fibrosis
Listed in LSHTM Data Compass
This projects aims to: (1) establish best practices for application of target trial emulation methodology using UK CF Registry data to estimate effects of treatments in cystic fibrosis.
Description
(2) apply the methods to emulate four existing RCTs that have been conducted assessing the effects of antibiotics. (3) extend Aim 2 to questions that have not yet been studied in RCTs, including to estimate longer-term effects of antibiotics and the effects in CFTR modulator users.
Links
Where it is published
- LSHTM Data Compass record datacompass.lshtm.ac.uk/id/eprint/4647/1/Protocol_TTE_Benchmarking_trials_in_CF.docx ↗
landing page · from lshtm ac uk
- DOI doi.org/10.17037/pubs.00004647 ↗
DOI / persistent id · from lshtm ac uk
Catalogue records · 1
- OAI-PMH record datacompass.lshtm.ac.uk/cgi/oai2?verb=GetRecord&metadataPrefix=oai_dc&identifier=oai%3… ↗
metadata API · from lshtm ac uk
Topics
- From keywords
- Earth & Environmental Science · Humanities · Life Sciences · Medicine & Health · Social Science
Provenance · 1 source records, 10 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| LSHTM Data Compass | oai:datacompass.lshtm.ac.uk:4647 | 11 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · lshtm ac uk | connector:lshtm_ac_uk@1.0.0 | |
| concepts[field].local:field:earth-environmental | mapping · lshtm ac uk | connector:lshtm_ac_uk@1.0.0 | |
| concepts[field].local:field:humanities | mapping · lshtm ac uk | connector:lshtm_ac_uk@1.0.0 | |
| concepts[field].local:field:life-sciences | mapping · lshtm ac uk | connector:lshtm_ac_uk@1.0.0 | |
| concepts[field].local:field:medicine-health | mapping · lshtm ac uk | connector:lshtm_ac_uk@1.0.0 | |
| concepts[field].local:field:social-science | mapping · lshtm ac uk | connector:lshtm_ac_uk@1.0.0 | |
| description | source · lshtm ac uk | connector:lshtm_ac_uk@1.0.0 | /metadata/dc/description |
| license | source · lshtm ac uk | connector:lshtm_ac_uk@1.0.0 | /metadata/dc/rights |
| publication_date | source · lshtm ac uk | connector:lshtm_ac_uk@1.0.0 | |
| title | source · lshtm ac uk | connector:lshtm_ac_uk@1.0.0 | /metadata/dc/title |