Data · dataset · 2022
MicroRNA-146a directs the symmetrical division of Snail-dominant colorectal cancer stem cells.
Listed in NYCU Dataverse
Asymmetrical cell division (ACD) maintains the proper number of stem cells to ensure self-renewal.
Description
In cancer cells, the deregulation of ACD disrupts the homeostasis of the stem cell pool and promotes tumour growth. However, this mechanism is unclear.
Here, we show a reduction of ACD in spheroid-derived colorectal cancer stem cells (CRCSCs) compared with differentiated cancer cells. The epithelial-mesenchymal transition (EMT) inducer Snail is responsible for the ACD-to-symmetrical cell division (SCD) switch in CRCSCs. Mechanistically, Snail induces the expression of microRNA-146a (miR-146a) through the β-catenin-TCF4 complex. miR-146a targets Numb to stabilize β-catenin, which forms a feedback circuit to maintain Wnt activity and directs SCD.
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Interference with the Snail-miR-146a–β-catenin loop by inhibiting the MEK or Wnt activity reduces the symmetrical division of CRCSCs and attenuates tumorigenicity. In colorectal cancer patients, the Snail(High)Numb(Low) profile is correlated with cetuximab resistance and a poorer prognosis. This study elucidates a unique mechanism of EMT-induced CRCSC expansion.
Links
Where it is published
- Dataverse dataset page dataverse.lib.nycu.edu.tw/dataset.xhtml?persistentId=doi%3A10.57770%2F7ZHNTV ↗
landing page · from dataverse lib nycu edu tw
- DOI doi.org/10.57770/7zhntv ↗
DOI / persistent id · from dataverse lib nycu edu tw
Catalogue records · 1
- Dataverse API dataverse.lib.nycu.edu.tw/api/datasets/:persistentId/?persistentId=doi%3A10.57770%2F7ZHN… ↗
metadata API · from dataverse lib nycu edu tw
Topics
- Stated by source
- Medicine, Health and Life Sciences
- From keywords
- Life Sciences · Medicine & Health
- Inferred from text
- Cancer 75%
Provenance · 1 source records, 10 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NYCU Dataverse | doi:10.57770/7ZHNTV | 16 h ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| concepts[disease].local:disease:cancer | enrichment · dataverse lib nycu edu tw | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[field].dataverse_subject:medicine-health-and-life-sciences | source · dataverse lib nycu edu tw | connector:dataverse_lib_nycu_edu_tw@1.0.0 | /subjects |
| concepts[field].local:field:life-sciences | mapping · dataverse lib nycu edu tw | connector:dataverse_lib_nycu_edu_tw@1.0.0 | /subjects |
| concepts[field].local:field:medicine-health | mapping · dataverse lib nycu edu tw | connector:dataverse_lib_nycu_edu_tw@1.0.0 | /subjects |
| created_date | source · dataverse lib nycu edu tw | connector:dataverse_lib_nycu_edu_tw@1.0.0 | |
| description | source · dataverse lib nycu edu tw | connector:dataverse_lib_nycu_edu_tw@1.0.0 | /description |
| publication_date | source · dataverse lib nycu edu tw | connector:dataverse_lib_nycu_edu_tw@1.0.0 | |
| title | source · dataverse lib nycu edu tw | connector:dataverse_lib_nycu_edu_tw@1.0.0 | /name |
| updated_date | source · dataverse lib nycu edu tw | connector:dataverse_lib_nycu_edu_tw@1.0.0 | |
| version_label | source · dataverse lib nycu edu tw | connector:dataverse_lib_nycu_edu_tw@1.0.0 |