An upward 9.4 T static magnetic field inhibits DNA synthesis and increases ROS-P53 to suppress lung cancer growth

Meanwhile, emerging experimental evidences show that moderate to high intensity Static MagneticFields (SMFs) have some anti-cancer effects.We examined the effects of two opposite SMF directions on lung cancer bearing mice and found when the lungcancer cell-bearing mice were treated with 9.4 T SMFs for 88 h in total, the upward 9.4 T SMF significantlyinhibited A549 tumor growth (tumor growth inhibition=41%), but not the downward 9.4 T SMF.

In vitro cellularanalysis shows that 9.4 T upward SMF treatment for 24 h not only inhibited A549 DNA synthesis, but alsosignificantly increased ROS and P53 levels, and arrested G2 cell cycle. Moreover, the 9.4 T SMF-treatments for88 h had no severe impairment to the key organs or blood cell count of the mice.Our findings demonstrated the safety of 9.4 T SMF long-term exposure for their future applications in MRI, andrevealed the anti-cancer potential of the upward direction 9.4 T SMF.