Data · dataset · 2024
Age-related immune clearance of hepatitis B virus infection requires the establishment of gut microbiota.
Listed in NYCU Dataverse
A unique feature of hepatitis B virus (HBV) infection in humans is that viral clearance heavily depends on the age of exposure.
Description
However, the reason for this remains unclear. Here we show that gut microbiota contribute to the age dependence of HBV immunity in a hydrodynamic transfection mouse model.
Although adult (12-wk-old) C3H/HeN mice cleared HBV within 6 wk postinjection (wpi), their young (6-wk-old) counterparts remained HBV-positive at 26 wpi. Sterilization of gut microbiota from 6 to 12 wk of age using antibiotics prevented adult mice from rapidly clearing HBV. Young mice with the Toll-like-receptor (TLR) 4 mutation (C3H/HeJ) exhibited rapid HBV clearance.
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The results suggest that an immuno-tolerating pathway to HBV prevailed in young mice, before the establishment of gut bacteria, through a TLR4-dependent pathway and that the maturation of gut microbiota in adult mice stimulated liver immunity, resulting in rapid HBV clearance.
Links
Where it is published
- Dataverse dataset page dataverse.lib.nycu.edu.tw/dataset.xhtml?persistentId=doi%3A10.57770%2F6PI80A ↗
landing page · from dataverse lib nycu edu tw
- DOI doi.org/10.57770/6pi80a ↗
DOI / persistent id · from dataverse lib nycu edu tw
Catalogue records · 1
- Dataverse API dataverse.lib.nycu.edu.tw/api/datasets/:persistentId/?persistentId=doi%3A10.57770%2F6PI8… ↗
metadata API · from dataverse lib nycu edu tw
Topics
- Stated by source
- Medicine, Health and Life Sciences
- From keywords
- Life Sciences · Medicine & Health
Provenance · 1 source records, 9 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NYCU Dataverse | doi:10.57770/6PI80A | 15 h ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| concepts[field].dataverse_subject:medicine-health-and-life-sciences | source · dataverse lib nycu edu tw | connector:dataverse_lib_nycu_edu_tw@1.0.0 | /subjects |
| concepts[field].local:field:life-sciences | mapping · dataverse lib nycu edu tw | connector:dataverse_lib_nycu_edu_tw@1.0.0 | /subjects |
| concepts[field].local:field:medicine-health | mapping · dataverse lib nycu edu tw | connector:dataverse_lib_nycu_edu_tw@1.0.0 | /subjects |
| created_date | source · dataverse lib nycu edu tw | connector:dataverse_lib_nycu_edu_tw@1.0.0 | |
| description | source · dataverse lib nycu edu tw | connector:dataverse_lib_nycu_edu_tw@1.0.0 | /description |
| publication_date | source · dataverse lib nycu edu tw | connector:dataverse_lib_nycu_edu_tw@1.0.0 | |
| title | source · dataverse lib nycu edu tw | connector:dataverse_lib_nycu_edu_tw@1.0.0 | /name |
| updated_date | source · dataverse lib nycu edu tw | connector:dataverse_lib_nycu_edu_tw@1.0.0 | |
| version_label | source · dataverse lib nycu edu tw | connector:dataverse_lib_nycu_edu_tw@1.0.0 |