Normal-inverse bimodule operation Hadamard transform ion mobility spectrometry

In this novel technique, anormal and inverse pseudo random binary sequence (PRBS) was produced in sequential order by an iongate controller and utilized to control the ion gate of IMS, and then the normal HT-IMS mobility spectrumand the inverse HT-IMS mobility spectrum were obtained.

A NIBOHT-IMS mobility spectrum was gainedby subtracting the inverse HT-IMS mobility spectrum from normal HT-IMS mobility spectrum. Experimental results demonstrate that the NIBOHT-IMS technique can signifificantly suppress or eliminate thespurious peaks, and enhance the SNR by measuring the reactant ions. Furthermore, the gas CHCl3 andCH2Br2 were measured for evaluating the capability of detecting real sample.