Data Sheet 1_Association of the GLM7 composite metabolic index with gestational diabetes mellitus in early pregnancy: a secondary analysis of a Korean prospective pregnancy cohort.docx

RCS analysis showed no evidence of departure from linearity (p for non-linearity = 0.266). The association persisted across sensitivity and subgroup analyses. The E-value of 28.03 suggested that only a very strong unmeasured confounder could nullify the observed association.

ROC analysis revealed an AUC of 0.839 (95% CI 0.767–0.912) for GLM7. Pairwise DeLong comparisons showed significantly higher AUCs for GLM7 than for HOMA-IR and for first-trimester fasting plasma glucose (FPG), while differences compared with the TyG index, fatty liver index (FLI), and hepatic steatosis index (HSI) were not statistically significant. Within this cohort, the optimal GLM7 threshold was 6.932, yielding 77.8% sensitivity and 78.2% specificity.</p>Conclusions<p>GLM7 was independently associated with subsequent GDM.</p>