Omics · dataset · 2026
Levofloxacin: reducing the risk of Pseudomonas aeruginosa resistance
Listed in ZivaHub and Deakin Research Online and DMU Figshare — shown once because both records carry DOI 10.17034/32640240.v1
<i>Pseudomonas aeruginosa</i> (<i>P. aeruginosa</i>) is a common cause of airway infections in people with cystic fibrosis (pwCF).
Description
Nebulised levofloxacin is the latest inhaled antibiotic available to manage chronic <i>P. aeruginosa</i> infections in pwCF. Little data is currently available on how this therapy is practically used in CF clinics or how <i>P. aeruginosa</i> isolates respond to levofloxacin exposure and the impact of antibiotic rotation during the administration of long-term inhaled antibiotic regimens.
This thesis aimed to (i) determine how inhaled antibiotics are currently used in CF centres across Europe and the place of nebulised levofloxacin in the treatment of chronic <i>P. aeruginosa</i> infections, (ii) the impact of <i>in vitro</i> levofloxacin exposure and subsequent antibiotic rotation on levofloxacin resistance development in clinical <i>P. aeruginosa</i> isolates from pwCF, and (iii) the underlying genomic mechanisms contributing to levofloxacin resistance.
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The results of this thesis aim to provide an insight into the current use of nebulised levofloxacin in the clinic as well as a better understanding of the development of <i>in vitro</i> levofloxacin resistance in <i>P. aeruginosa</i> and the genetic mechanisms contributing to this. These results could inform the design of future inhaled antibiotic regimens to reduce the risk of resistance development in <i>P. aeruginosa</i> and ensure continued efficacy for current and future pwCF.<br><br><i>Thesis is embargoed until 31st December 2027</i>.<br><br><br>
Links
Where it is published
- DOI doi.org/10.17034/32640240.v1 ↗
DOI / persistent id · from zivahub uct ac za
Catalogue records · 1
- OAI-PMH record api.figshare.com/v2/oai?verb=GetRecord&metadataPrefix=oai_dc&identifier=oai%3Af… ↗
metadata API · from zivahub uct ac za
Topics
Provenance · 3 source records, 14 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| ZivaHub | oai:figshare.com:article/32640240 | 8 d ago | JSON v1 |
| Deakin Research Online | oai:figshare.com:article/32640240 | 8 d ago | JSON v1 |
| DMU Figshare | oai:figshare.com:article/32640240 | 8 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | |
| concepts[field].local:field:earth-environmental | mapping · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | |
| concepts[field].local:field:earth-environmental | mapping · figshare dmu ac uk | connector:figshare_dmu_ac_uk@1.0.0 | |
| concepts[field].local:field:earth-environmental | mapping · dro deakin edu au | connector:dro_deakin_edu_au@1.0.0 | |
| concepts[field].local:field:life-sciences | mapping · dro deakin edu au | connector:dro_deakin_edu_au@1.0.0 | |
| concepts[field].local:field:life-sciences | mapping · figshare dmu ac uk | connector:figshare_dmu_ac_uk@1.0.0 | |
| concepts[field].local:field:life-sciences | mapping · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | |
| concepts[modality].local:modality:genome-sequencing | mapping · figshare dmu ac uk | vocabulary-mapper@1.0.0 | keywords['whole genome sequencing'] |
| concepts[modality].local:modality:genome-sequencing | mapping · zivahub uct ac za | vocabulary-mapper@1.0.0 | keywords['whole genome sequencing'] |
| concepts[modality].local:modality:genome-sequencing | mapping · dro deakin edu au | vocabulary-mapper@1.0.0 | keywords['whole genome sequencing'] |
| description | source · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | /metadata/dc/description |
| license_text | source · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | |
| publication_date | source · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | |
| title | source · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | /metadata/dc/title |