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Data · dataset · 2018

Supplementary data to publication “An approximate Bayesian significance test for genomic evaluations” (Biom J)

Listed in RADAR and RADAR4Memory — shown once because both records carry DOI 10.22000/80

A simulation study has been conducted to analyse the association between genetic and phenotypic variation in livestock.

Description

Following the density and distribution of single nucleotide polymorphisms (SNPs) on the Illumina BovineSNP50 chip, 52,773 SNPs were simulated on the cattle genome of 30 Morgan length. Several generations of random mating were executed in which random recombination events according to the genetic distance between SNPs and random mutation of SNP alleles were considered.

In the most recent generations, 50 sires were mated to 20 dams in order to generate multiple half-sib families. The data were split into training (n=2,000) and validation/testing set (n=2,000). Twenty-three SNPs were randomly preselected to be the causative variants, and additive, dominance and epistatic effects were simulated.

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Two different traits were achieved by adding different residual error terms to the sum of genetic effects, such that the total genetic variation contributed either 30% or 50% to the phenotypic variation. Then, 5,227 SNPs (every 10-th SNP including the causative variants) were selected. The simulation was repeated 100 times.

More details can be found in Wittenburg et al. (2011) Including non-additive genetic effects in Bayesian methods for the prediction of genetic values based on genome-wide markers. BMC Genetics 12:74, doi.org/10.1186/1471-2156-12-74

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Where it is published

Catalogue records · 1

Topics

Inferred from text
Simulation 75%
Provenance · 2 source records, 12 field assertions
SourceKeyLast seenRaw
RADAR10.22000/8010 d agoJSON v1
RADAR4Memory10.22000/8010 d agoJSON v1
FieldAssertionExtractorEvidence
access_levelsource · radar service eu deconnector:radar_service_eu_de@1.0.0
concepts[field].anzsrc:group:3105mapping · radar service eu devocabulary-mapper@1.0.0keywords['Genetics']
concepts[field].anzsrc:group:3105mapping · radar4memory radar service euvocabulary-mapper@1.0.0keywords['Genetics']
concepts[field].local:field:earth-environmentalmapping · radar4memory radar service euconnector:radar4memory_radar_service_eu@1.0.0
concepts[field].local:field:earth-environmentalmapping · radar service eu deconnector:radar_service_eu_de@1.0.0
concepts[field].local:field:life-sciencesmapping · radar service eu deconnector:radar_service_eu_de@1.0.0
concepts[field].local:field:life-sciencesmapping · radar4memory radar service euconnector:radar4memory_radar_service_eu@1.0.0
concepts[method].local:method:simulationenrichment · radar service eu dekeyword-concept-rules@1.0.0title+description (75%)
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