Accurate multiple sclerosis atrophy measurement system

Besides physiological variability, differences between MRI scanners and acquisition methods are particular hurdles to reliably measure within-patient brain volume changes longitudinally. There is inconsistency between atrophy measurements of a patient scanned using different MR systems or at the same system but using different measurement (i.e., image acquisition) methods.

This inconsistency decreases the statistical power in multi-center studies and hampers the use of atrophy measurements in personalized diagnosis, prognosis and treatment of the MS patients. This dataset contained 30 pwMS and 10 HC to validate a new standardization method to reliably measure atrophy across scanners and acquisition methods. After this validation, data from MS patients across the world can be accumulated and combined into a reference database that can be used.