Sequence alignment analysis on human Dicer

Red triangles mark the highly conserved amino acids in all the RNase III domains responsible for binding magnesium ions. Blue triangles indicate the residues responsible for dimerization. Figure two: Conservation of hDicer DExD/H-box helicase domain with its homologues.

Sequence alignment among the helicase domains of RLH family members. Figure three: Conservation of Dicer’s DExD/H-box helicase domains among different species. Sequence alignment of DExD/H-box helicase domains from human, mouse, zebrafish, chicken, Arabidopsis and Drosophila.