Database for "The impact of amino acids on postprandial glucose and insulin kinetics in humans: a quantitative overview"

A quantitative comparison of the effects of AAs on glucose and insulin kinetics in humans is currently lacking. PubMed was queried to identify intervention studies reporting glucose and insulin concentrations after acute ingestion and/or intravenous infusion of AAs in healthy adults and those living with obesity and/or type 2 diabetes (T2DM).

The systematic literature search identified 55 studies that examined the effects of L-leucine, L-isoleucine, L-alanine, L-glutamine, L-arginine, L-lysine, glycine, L-proline, L-phenylalanine, L-glutamate, branched-chain AAs (i.e., L-leucine, L-isoleucine, and L-valine), and multiple individual L-AAs on glucose and insulin concentrations. Oral ingestion of most individual AAs induced an insulin response but did not alter glucose concentrations in healthy participants.