Data · dataset · 2026
Picolinate- and Phosphonated Pyridyl-TACN Ligands for Highly Stable and Inert Cu(II) Complexes for Radiochemical Applications
Listed in ZivaHub
In this study, three novel chelators based on the 1,4,7-triazacyclononane (TACN) ligand platform were introduced.
Description
The ligands contain picolinate and phosphonated pyridine chelating arms to provide an optimal five-coordinate geometry for Cu(II). The solution chemistry of these complexes was systematically investigated using spectrophotometric titrations, UV-vis spectroscopy, electron paramagnetic resonance (EPR), and cyclic voltammetry (CV).
Then, these ligands were employed in <sup>64</sup>Cu radiolabeling studies and subsequent <i>in vivo</i> positron emission tomography (PET) imaging studies to reveal that the <sup>64</sup>Cu complexes of the two phosphonated pyridine-TACN ligands were excreted via the renal pathway, while the picolinate-TACN analogue exhibited a shift in the excretion pathway due to its lipophilic nature, resulting in partial liver excretion.
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To our knowledge, the use of phosphonated pyridines as chelators in <sup>64</sup>Cu PET imaging is uncommon, which underscores the significance of this study.
Links
Where it is published
- DOI doi.org/10.1021/acs.inorgchem.6c03664.s001 ↗
DOI / persistent id · from zivahub uct ac za
Catalogue records · 1
- OAI-PMH record api.figshare.com/v2/oai?verb=GetRecord&metadataPrefix=oai_dc&identifier=oai%3Af… ↗
metadata API · from zivahub uct ac za
Topics
- From keywords
- Biochemistry and cell biology · Chemistry · Earth & Environmental Science · Life Sciences · Social Science · Sociology · Solution chemistry
- Inferred from text
- Imaging 75%
Provenance · 1 source records, 13 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| ZivaHub | oai:figshare.com:article/34025350 | 12 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | |
| concepts[field].anzsrc:field:340608 | mapping · zivahub uct ac za | vocabulary-mapper@1.0.0 | keywords['solution chemistry'] |
| concepts[field].anzsrc:group:3101 | mapping · zivahub uct ac za | vocabulary-mapper@1.0.0 | keywords['Cell Biology'] |
| concepts[field].anzsrc:group:4410 | mapping · zivahub uct ac za | vocabulary-mapper@1.0.0 | keywords['Sociology'] |
| concepts[field].local:field:chemistry | mapping · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | |
| concepts[field].local:field:earth-environmental | mapping · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | |
| concepts[field].local:field:life-sciences | mapping · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | |
| concepts[field].local:field:social-science | mapping · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | |
| concepts[modality].local:modality:imaging | enrichment · zivahub uct ac za | keyword-concept-rules@1.0.0 | title+description (75%) |
| description | source · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | /metadata/dc/description |
| license | source · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | /metadata/dc/rights |
| publication_date | source · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | |
| title | source · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | /metadata/dc/title |