Data · dataset · 2020
Heme Oxygenase-1 counteracts contrast-induced acute kidney injury in diabetic rats via antioxidant pathway
Listed in Teesside University Research Data Repository
Contrast-induced acute kidney injury (CI-AKI) is the third leading cause of hospital-acquired kidney injury.
Description
Diabetes Mellitus is an important risk factor for contrast-induced acute kidney injury and its identification is predictable. Heme oxygenase-1 (HO-1) is a new therapeutic target that exerts antioxidant effect against kidney diseases.
This study investigated the effect of HO-1 on metabolic functions, oxidative profile and morphology at CI-AKI in the presence of Diabetes Mellitus. Twenty-eight male Wistar rats weighing 250-300g were randomized into four groups: C (control)- rats submitted to left uninephrectomy on the 1th day; DM- Diabetes was induced by a single dose of intravenous streptozotocin-65mg/kg on the 20th day; DMIC- iodinated contrast- meglumine ioxithalamate (6ml/kg, intraperitoneal, once) rats and DMICH- hemin (HO-1 inducer; 10mg/kg; intraperitoneal; 60 minutes before iodinated contrast) were infused on the 85th day.
Read the rest (2 more)
Diabetic groups showed polyphagia, polydipsia, polyuria, and increase in the blood glucose and in the kidney/animal weight ratio. Iodinated contrast reduced the creatinine clearance and thiols in renal tissue with a prominent increase in urinary NGAL, peroxides, oxide nitric and thiobarbituric acid-reactive substances (TBARS), these parameters were significantly changed by HO-1 inducer. Kidney histology showed tubular cells vacuolization and edema in iodinated contrast animals.
The data highlight the HO-1 protective effect against contrast-induced AKI associated with chronic disease, DM.
Links
Where it is published
- DOI doi.org/10.17632/vfvk3f97nh.1 ↗
DOI / persistent id · from researchdata tees ac uk
Catalogue records · 1
- OAI-PMH record data.mendeley.com/oai?verb=GetRecord&metadataPrefix=oai_dc&identifier=oai%3Adata… ↗
metadata API · from researchdata tees ac uk
Topics
- From keywords
- Earth & Environmental Science · Medicine & Health
- Inferred from text
- Disease 75%
Provenance · 1 source records, 8 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| Teesside University Research Data Repository | oai:data.mendeley.com/vfvk3f97nh.1 | 9 h ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · researchdata tees ac uk | connector:researchdata_tees_ac_uk@1.0.0 | |
| concepts[disease].local:disease:disease | enrichment · researchdata tees ac uk | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[field].local:field:earth-environmental | mapping · researchdata tees ac uk | connector:researchdata_tees_ac_uk@1.0.0 | |
| concepts[field].local:field:medicine-health | mapping · researchdata tees ac uk | connector:researchdata_tees_ac_uk@1.0.0 | |
| description | source · researchdata tees ac uk | connector:researchdata_tees_ac_uk@1.0.0 | /metadata/dc/description |
| license | source · researchdata tees ac uk | connector:researchdata_tees_ac_uk@1.0.0 | /metadata/dc/rights |
| publication_date | source · researchdata tees ac uk | connector:researchdata_tees_ac_uk@1.0.0 | |
| title | source · researchdata tees ac uk | connector:researchdata_tees_ac_uk@1.0.0 | /metadata/dc/title |