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Text · dataset · 2010

CRASH-2 - Clinical Randomisation of an Antifibrinolytic in Significant Haemorrhage

Listed in LSHTM Data Compass

A large randomised placebo controlled trial among trauma patients with or at risk of significant haemorrhage, of the effects of antifibrinolytic treatment on death and transfusion requirement.

Description

CRASH-2 is a randomised, controlled, double-blind trial undertaken in 274 hospitals in 40 countries. A total of 20211 adult trauma patients, with, or at risk of, significant bleeding (haemorrhage) were randomly assigned within 8 hours of injury to either tranexamic acid (TXA) or matching placebo.

The primary outcome was death in hospital within four weeks of injury and was described with the following categories: bleeding, vascular occlusion (myocardial infarction, stroke and pulmonary embolism), multiorgan failure, head injury, and other. This dataset is available at freebird.lshtm.ac.uk/index.php/data-sharing/downloads/crash2/

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Topics

Inferred from text
Myocardial infarction 75%
Provenance · 1 source records, 11 field assertions
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FieldAssertionExtractorEvidence
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