Data · dataset · 2026
<p>Replication-based drug sensitivity profiling of <i>Pf</i>ATG18-deficient parasites.</p>
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<p>(A-D) Drug sensitivity assays with induction and drug addition at 16 hours post-invasion and readout in the second cycle (A) show that <i>Pf</i>ATG18-deficient parasites exhibit unaltered responses to WR99210 (B), chloroquine (C), and DHA (D).
Description
(E-H) Delaying drug addition until the schizont stage (E) likewise reveals no changes in drug response (F-H). (I,J) Drug sensitivity assays with ring-stage induction, drug addition at the onset of DV fragmentation, and readout at the end of the first cycle (I) reveal no change in DHA sensitivity following <i>Pf</i>ATG18 loss (J).
IC<sub>50</sub> values were determined by non-linear regression. Mean + /- SEM; n = 3 experiments with 3 technical replicates each. n.s., <i>p</i> > 0.05.</p> <p>(TIF)</p>
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Where it is published
- DOI doi.org/10.1371/journal.ppat.1014608.s006 ↗
DOI / persistent id · from zivahub uct ac za
Catalogue records · 1
- OAI-PMH record api.figshare.com/v2/oai?verb=GetRecord&metadataPrefix=oai_dc&identifier=oai%3Af… ↗
metadata API · from zivahub uct ac za
Topics
Provenance · 1 source records, 12 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| ZivaHub | oai:figshare.com:article/34017812 | 11 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | |
| concepts[field].anzsrc:field:320211 | mapping · zivahub uct ac za | vocabulary-mapper@1.0.0 | keywords['Infectious Diseases'] |
| concepts[field].anzsrc:group:3101 | mapping · zivahub uct ac za | vocabulary-mapper@1.0.0 | keywords['Cell Biology'] |
| concepts[field].anzsrc:group:3105 | mapping · zivahub uct ac za | vocabulary-mapper@1.0.0 | keywords['Genetics'] |
| concepts[field].anzsrc:group:3107 | mapping · zivahub uct ac za | vocabulary-mapper@1.0.0 | keywords['Microbiology'] |
| concepts[field].local:field:earth-environmental | mapping · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | |
| concepts[field].local:field:life-sciences | mapping · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | |
| concepts[field].local:field:medicine-health | mapping · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | |
| description | source · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | /metadata/dc/description |
| license | source · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | /metadata/dc/rights |
| publication_date | source · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | |
| title | source · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | /metadata/dc/title |