The cKIT kinase inhibitor CHMFL-KIT-64 was used in the treatment of gastrointestinal stromal tumors dataset

Synthesis and characterization of compounds；Antiproliferative effects of compounds CHMFL-KIT-64 against a panel of c-KIT wt/c-KIT-T670I BaF3 cells；Selectivity profiling of compound CHMFL-KIT-64；Antiproliferation effects of compounds antiproliferation efects of compounds CHMFL-KIT-64 against a variety of GIST cancer cell lines；Cellular evaluation of compound CHMFL-KIT-64(for example cell cycle progression, apoptosis and signaling pathways);Antiproliferative effects of compounds CHMFL-KIT-64 against primary cells derived from GIST patients;In vivo PK/PD and efficacy evaluation of compound CHMFL-KIT-64;PK study of compound CHMFL-KIT-64 in mice, sprague dawley rats, and beagle dogs;Antitumor efficacy of CHMFL-KIT-64 in the BaF3-tel-c-KIT-T670I, BaF3-tel-c-KIT-D820G and BaF3-tel-c-KIT-Y823D xenograft mouse model.