Clinical Investigation of Early Vascular Endothelial Injury in Patients with Asymptomatic Hyperuricemia

The results showed that the levels of FMD in the asymptomatic hyperuricemia group were significantly lower than those in the control group, while the levels of endothelin-1, von Willebrand factor, soluble vascular cell adhesion molecule-1, IL-6, tumor necrosis factor - α and other inflammatory factors were significantly higher than those in the control group (all P<0.001); After controlling for confounding factors, blood uric acid was found to be an independent risk factor for endothelial injury (β=-0.013, P<0.001); IL-6 plays a partial mediating role between blood uric acid and endothelial injury, with the mediating effect accounting for 35.5% of the total effect.

The Sobel test showed statistically significant differences (Z=-3.220, P=0.001). Conclusion: In the stage of asymptomatic hyperuricemia, clear early damage to the vascular endothelium has appeared, and blood uric acid can exacerbate endothelial function damage by inducing chronic low-grade immune inflammatory response mediated by IL-6; The combined detection of blood uric acid and inflammatory factors can be used for early screening and risk assessment of vascular injury in high-risk populations.