Schisandrin B Exacerbates Acute Pancreatitis by Driving Pathological Pancreatic Secretion

Blood serum and pancreata were collected for further studies, including H&E (pancreata), IHC (pancreata, CD45), Biochemical study (serum, α-amylase activity), and RNA-Seq (pancreata).

Data description

In folder "pancreata_H&E_pathology scoring", include: high power fields (HPFs) images for each mice. The numbering information, scoring raw data, data processing can be found in the excel. In folder" pancreata_IHC_CD45", include: HFPs images for each mice.

The numbering information, image-pro-plus setting parameters for macro-detecting positive cells. The detail information (raw data, data processing and summary of CD45 positive ratio ) is presented in the excel. In folder" supplemental tables", include: H&E injury area, α-amylase detection, supplementary_Table1 (RNA-Seq, all significant DEGs list), Supplementary_Table2(RNA-Seq, significantly enriched KEGG pathway list) Conclusion: SchB exacerbates acute pancreatitis, potentially by transcriptionally promoting the overproduction of digestive enzymes and enhancing pancreatic auto-digestion.