Data · dataset · 2022
Photogenerated-hole-induced rapid elimination of solid tumors by the supramolecular porphyrin photocatalyst
Listed in ScienceDB
Te rapid, complete, targeted and safe treatment for tumors remains a key issue in cancer therapy.
Description
A noveltreatment of solid tumors by supramolecular photocatalyst Nano-SA-TCPP with the irradiation of600–700 nm wavelength is established. Solid tumors (100 mm3) can be eliminated within 10 min.
Te50-day mouse survival rate was increased from 0% to 100% afer the photocatalytic therapy. Tebreakthrough was owing to the cell membrane rupture and the cytoplasmic loss caused by photogeneratedholes inside cancer cells. Te porphyrin-based photocatalysts can be internalized in a targeted manner bycancer cells due to the size selection effect, without entering the normal cells.
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Te therapy has no toxicity orside effects for normal cells and organisms. Moreover, the photocatalytic therapy is effective for a variety ofcancer cell lines. Because of its high efciency, safety and universality, the photocatalytic therapy providesus with a new lancet to conquer the tumor.
Links
Where it is published
- DOI doi.org/10.57760/sciencedb.03156 ↗
DOI / persistent id · from scidb cn
Catalogue records · 1
- OAI-PMH record scidb.cn/oai?verb=GetRecord&metadataPrefix=oai_dc&identifier=10.57760%2… ↗
metadata API · from scidb cn
Topics
- From keywords
- Earth & Environmental Science · Engineering · Humanities · Life Sciences · Social Science
- Inferred from text
- Cancer 75%
Provenance · 1 source records, 11 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| ScienceDB | 10.57760/sciencedb.03156 | 10 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · scidb cn | connector:scidb_cn@1.0.0 | |
| concepts[disease].local:disease:cancer | enrichment · scidb cn | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[field].local:field:earth-environmental | mapping · scidb cn | connector:scidb_cn@1.0.0 | |
| concepts[field].local:field:engineering | mapping · scidb cn | connector:scidb_cn@1.0.0 | |
| concepts[field].local:field:humanities | mapping · scidb cn | connector:scidb_cn@1.0.0 | |
| concepts[field].local:field:life-sciences | mapping · scidb cn | connector:scidb_cn@1.0.0 | |
| concepts[field].local:field:social-science | mapping · scidb cn | connector:scidb_cn@1.0.0 | |
| description | source · scidb cn | connector:scidb_cn@1.0.0 | /metadata/dc/description |
| license | source · scidb cn | connector:scidb_cn@1.0.0 | /metadata/dc/rights |
| publication_date | source · scidb cn | connector:scidb_cn@1.0.0 | |
| title | source · scidb cn | connector:scidb_cn@1.0.0 | /metadata/dc/title |