Development of responsive biomaterials capable of triggered self-cleaning

Application of these devices can be a risk factor to induce device-associated infections resulting in increasing death rates and medical costs in the healthcare system. In this work, we aims to develop a responsive biomaterial capable of triggered self- cleaning on the surface of indwelling catheters.

By detecting the pH elevation at the onset of infection, the release of antimicrobials can be switched on specifically to reduce the risk of infections. Results have demonstrated that by applying this strategy as a hydrogel coating on silicone surface, reduced coefficient of friction and anti-adherence effectiveness against both P. mirabilis and S. aureus strains were achieved. Development of pH-responsive drug delivery hydrogel in this work offered a promising contribution to addressing problems related to device-associated infections.<br><br><i>Thesis is embargoed until 31 December 2028</i>.<br><br>