Data · dataset · 2024
Development and characterization of oral film for the local release of simvastatin
Listed in REDU - Unicamp Institutional Research Data Repository
The development of stable and easy-to-apply mucoadhesive oral systems is challenging and necessary for the treatment of oral pathologies.
Description
Simvastatin (SMV) is a drug that has demonstrated potential for use in this region. Thus, the objective was to develop a chitosan-based oral film incorporated with SMV emulsion for sustained drug release.
The films were produced by solvent casting, using 1% chitosan and 2.5% SMV emulsion (90:10) (FM_SMV). The control group (FM_BLK) had the same composition, without SMV. The characterization of the film involved the description of the physical properties, analysis by Scanning Electron Microscopy (SEM) and Atomic Force Microscopy (AFM), Fourier Transform Infrared Spectroscopy (FT-IR), mechanical strength, analysis of content and release profile and evaluation of antimicrobial properties against oral microorganisms.
Links
Where it is published
- Dataverse dataset page redu.unicamp.br/dataset.xhtml?persistentId=doi%3A10.25824%2Fredu%2F8O5FAE ↗
landing page · from redu unicamp br
- DOI doi.org/10.25824/redu/8o5fae ↗
DOI / persistent id · from redu unicamp br
Catalogue records · 1
- Dataverse API redu.unicamp.br/api/datasets/:persistentId/?persistentId=doi%3A10.25824%2Fredu… ↗
metadata API · from redu unicamp br
Topics
- Stated by source
- Chemistry · Medicine, Health and Life Sciences
- From keywords
- Chemistry · Engineering · Life Sciences · Medicine & Health
- Inferred from text
- Microscopy 75%
Provenance · 1 source records, 13 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| REDU - Unicamp Institutional Research Data Repository | doi:10.25824/redu/8O5FAE | 10 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| concepts[field].dataverse_subject:chemistry | source · redu unicamp br | connector:redu_unicamp_br@1.0.0 | /subjects |
| concepts[field].dataverse_subject:medicine-health-and-life-sciences | source · redu unicamp br | connector:redu_unicamp_br@1.0.0 | /subjects |
| concepts[field].local:field:chemistry | mapping · redu unicamp br | connector:redu_unicamp_br@1.0.0 | /subjects |
| concepts[field].local:field:engineering | mapping · redu unicamp br | connector:redu_unicamp_br@1.0.0 | /subjects |
| concepts[field].local:field:life-sciences | mapping · redu unicamp br | connector:redu_unicamp_br@1.0.0 | /subjects |
| concepts[field].local:field:medicine-health | mapping · redu unicamp br | connector:redu_unicamp_br@1.0.0 | /subjects |
| concepts[modality].local:modality:microscopy | enrichment · redu unicamp br | keyword-concept-rules@1.0.0 | title+description (75%) |
| created_date | source · redu unicamp br | connector:redu_unicamp_br@1.0.0 | |
| description | source · redu unicamp br | connector:redu_unicamp_br@1.0.0 | /description |
| publication_date | source · redu unicamp br | connector:redu_unicamp_br@1.0.0 | |
| title | source · redu unicamp br | connector:redu_unicamp_br@1.0.0 | /name |
| updated_date | source · redu unicamp br | connector:redu_unicamp_br@1.0.0 | |
| version_label | source · redu unicamp br | connector:redu_unicamp_br@1.0.0 |