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Data · collection · 2015

Sesquiterpenes from the roots of Illicium oligandrum

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Two new sesquiterpenes, oligandrin ( 1 ) and oligandric acid ( 2 ), together with three analogues, tashironin A ( 3 ), tashironin ( 4 ), and oplodiol ( 5 ), were isolated from the roots of Illicium oligandrum .

Description

The structures of new compounds were determined based on 1D and 2D NMR experiments and X-ray diffraction. Compound 1 represents a presumed biosynthetic precursor of seco -prezizaane sesquiterpenes which consists of a novel 6/6/5 tricarbocyclic skeleton.

Compound 2 is the first example of chamipinene-type sesquiterpene possessing a 6/4/6 tricyclic system from the genus Illicium . Compounds 1 – 5 were evaluated in vitro for their activity against coxsackie virus B3 (CVB3), influenza virus A/Hanfang/359/95 (H3N2), and influenza virus A/FM/1/47 (H1N1). Compound 1 showed selective antiviral activity against CVB3 with IC 50 value of 11.11 μM.

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Provenance · 2 source records, 15 field assertions
SourceKeyLast seenRaw
DataCite10.6084/m9.figshare.c.206590112 d agoJSON v1
DataCite10.6084/m9.figshare.c.2065901.v112 d agoJSON v1
FieldAssertionExtractorEvidence
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concepts[field].fos:biological-sciencessource · DataCiteconnector:datacite@1.0.0
concepts[field].fos:biological-sciencessource · DataCiteconnector:datacite@1.0.0
concepts[field].fos:health-sciencessource · DataCiteconnector:datacite@1.0.0
concepts[field].fos:health-sciencessource · DataCiteconnector:datacite@1.0.0
concepts[field].local:field:chemistrymapping · DataCitevocabulary-mapper@1.0.0keywords['Chemistry']
concepts[field].local:field:chemistrymapping · DataCitevocabulary-mapper@1.0.0keywords['Chemistry']
concepts[field].local:field:life-sciencesmapping · DataCitevocabulary-mapper@1.0.0keywords['Biological Sciences']
concepts[field].local:field:life-sciencesmapping · DataCitevocabulary-mapper@1.0.0keywords['Biological Sciences']
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