Excel · study · 2026
Effect of the bile acids chenodeoxycholic acid (CDCA), deoxycholic acid (DCA) and cholic acid (CA) on the transcriptome of Mycobacterium avium strain MAC101
Listed in NCBI GEO
The bile acids chenodeoxycholic acid (CDCA), deoxycholic acid (DCA) andcholic acid (CA) were added to the growth medium of cultures of M.avium strain MAC101 and RNA was islated after 1.5 hours or 24 hours of incubation.
Description
RNAseq was performed with Illumina sequencing. With a FDR rate threshold of 0.05 showing a large number of genes whose expression was induced by the treatment.
The signature sets of induced genes or both bile acids are shown to be very different. there are also common responses in various genes that function in cholesterol catabolism. As a control cholesterol in a similar concentration was used but this had only a very moderate effect on the transcriptome at 1.5 hours.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE306nnn/GSE306124 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE306124 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1309496 ncbi.nlm.nih.gov/bioproject/PRJNA1309496 ↗
project · from NCBI GEO
Topics
- Stated by source
- Expression profiling by high throughput sequencing
- From keywords
- Life Sciences
- Inferred from text
- RNA sequencing 65% · Sequencing 75%
Provenance · 1 source records, 8 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE306124 | 11 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:expression-profiling-by-high-throughput-sequencing | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[modality].local:modality:rna-seq | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (65%) |
| concepts[modality].local:modality:sequencing | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |