Data · dataset · 2026
Augmenting radiation sensitivity of HPV-negative head and neck cancer through mannose intervention
Listed in ZivaHub and Deakin Research Online and DMU Figshare — shown once because both records carry DOI 10.17034/32639265.v1
This work demonstrates that mannose has the ability to sensitise HPV (-) HNSCC to radiation under normoxic and hypoxic conditions by ATP-dependent DNA damage repair and inhibiting HIF-1a.
Description
The metabolic profile of irradiated HNSCC cells further indicates that mannose interferes wit multiple metabolic pathways in the absence of functional phosphomannose isomerse (PMI). These findings highlight the potential of targeting PMI as an effective therapeutic target in combination with mannose-adjuvanted radiotherapy regimens. <br><br><i>Thesis is embargoed until 31 July 2029.</i><br>
Links
Where it is published
- DOI doi.org/10.17034/32639265.v1 ↗
DOI / persistent id · from zivahub uct ac za
Catalogue records · 1
- OAI-PMH record api.figshare.com/v2/oai?verb=GetRecord&metadataPrefix=oai_dc&identifier=oai%3Af… ↗
metadata API · from zivahub uct ac za
Topics
- From keywords
- Earth & Environmental Science · Earth & Environmental Science · Earth & Environmental Science
- Inferred from text
- Cancer 75%
Provenance · 3 source records, 9 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| ZivaHub | oai:figshare.com:article/32639265 | 11 d ago | JSON v1 |
| Deakin Research Online | oai:figshare.com:article/32639265 | 11 d ago | JSON v1 |
| DMU Figshare | oai:figshare.com:article/32639265 | 11 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | |
| concepts[disease].local:disease:cancer | enrichment · zivahub uct ac za | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[field].local:field:earth-environmental | mapping · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | |
| concepts[field].local:field:earth-environmental | mapping · dro deakin edu au | connector:dro_deakin_edu_au@1.0.0 | |
| concepts[field].local:field:earth-environmental | mapping · figshare dmu ac uk | connector:figshare_dmu_ac_uk@1.0.0 | |
| description | source · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | /metadata/dc/description |
| license_text | source · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | |
| publication_date | source · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | |
| title | source · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | /metadata/dc/title |